Optical Imaging
Laboratory
Department
of Electrical and Computer Engineering
Shanghai Jiao Tong University
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| Journal Papers |
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| 2026 |
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| 1. |
X.
Tang, T. Su, K. Zhang, J. Zhang, S. Liang, S.-L. Chen,
“Wide-field three-dimensional photoacoustic remote sensing
microscopy for industrial non-destructive testing based on a voice coil
motor” Opt. Lett. (under review) |
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| 2. |
[J.
Zhang, S. Tong, X. Tang], and S.-L. Chen, “Deep learning for
three-dimensional optical microscopy: a review,” Micro Nano
Manuf. 2, 5 (2026) [pdf] [link] |
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| 3. |
T.
Su, G. Chen, P. He, K. Zhang, Y. Ai, S.-L. Chen, C.-C. Tu,
“Laser-programmable wettability on porous silicon visualized by
photoacoustic microscopy,” Opt. Mater. 174, 117971 (2026) [pdf] [link] |
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| 4. |
[Z.
Li, P. He], Y. Yang, X. Yang, K. Zhang, T. Su, S. Tong, J. Cai, J.
Zhang, Y. Gao, S. Xing, and S.-L. Chen, “Photoacoustic imaging
for assessment of peripheral perfusion in human fingers during venous
and arterial occlusion,” Measurement 269, 120642 (2026) [pdf] [link] |
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| 5. |
[S.
Liang, N. Wan, G. Chen], S.-L. Chen, and M. Seong, “Sensing
changes in triglyceride concentration in blood solution using diffuse
optical spectroscopy,” Opt. Laser Technol. 197, 114767 (2026) [pdf] [link] |
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| 2025 |
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| 1. |
[J.
Zhou, X. Tang], X. Yu, S.-L. Chen, and S.-H. Bo,
“Three-dimensional operando photoacoustic microscopy reveals
hidden patterns in the complex electrochemical plating process of
lithium metal” J. Am. Chem. Soc. 147, 41492-41500 (2025) [pdf] [link] |
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| 2. |
Y.
Liu, J. Zhou, Y. Luo, S.-L. Chen, Y. Guo, and G.-Z. Yang,
“FPM-R2Net: Fused photoacoustic and operating microscopic imaging
with cross-modality representation and registration network,”
Med. Image Anal. 105, 103698 (2025) [pdf] [link] |
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| 3. |
[K.
Zhang, E. Tu], X. Fang, J. Zhou, W. Zhang, G.-Z. Yang, and S.-L. Chen,
“Optimized optical-acoustic combiner for high-sensitivity,
high-speed three-dimensional photoacoustic microscopy,” Opt.
Lett. 50, 5402-5405 (2025) [pdf] [link] |
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| 4. |
[X.
Tang, L. Zhang], D. He, B. Hu, C. Jia, S. Gu, J. Chen, R. Wu, and S.-L.
Chen, “Automatic generation and risk stratification of carotid
plaque in virtual shear wave elastography using a generative
adversarial network,” Comput. Med. Imaging Graph. 124, 102600 (2025) [pdf] [link] |
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| 5. |
[B.
Hu, H. Zhang, C. Jia, K. Chen], X. Tang, D. He, L. Zhang, S. Gu, J.
Chen, J. Zhang, R. Wu, and S.-L. Chen, “Automatic multi-task
segmentation and vulnerability assessment of carotid plaque on
contrast-enhanced ultrasound images and videos via deep
learning,” IEEE J. Biomed. Health Inform. (in press) [pdf] [link] |
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| 6. |
[S.
Liang, N. Wan, W. Pi], K. Zhang, J. Wen, S.-L. Chen, and M. Seong,
“Photoacoustic microscopy for visualization of stents in multiple
scenarios,” Opt. Lett. 50, 4722-4725 (2025) [pdf] [link] |
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| 7. |
[J.
Zhang, K. Zhang], X. Tang, J. Zhou, P. He, X. Tang, S. Liang, and S.-L.
Chen, “Physics-guided deep learning for three-dimensional
photoacoustic microscopy,” Laser Photonics Rev. 19, 2500352 (2025) [pdf] [link] |
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| 8. |
[S.
Liang, K. K. Park, W.-K. Lin], H. W. Baac, S.-L. Chen, and L. J. Guo,
“Photoacoustic sensing and transmission for biological and
industrial applications,” Device 3, 100831 (2025) [pdf] [link] |
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| 9. |
J.
Wen, M. Seong, G. Chen, and S.-L. Chen, “Low-cost diffuse optical
spectroscopy for assisting sclerotherapy: A proof-of-concept
study,” Opt. Laser Technol. 186, 112664 (2025) [pdf] [link] |
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| 2024 |
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| 1. |
G. Chen, P. He, C. Ma,
J. Xu, T. Su, J. Wen, H.-C. Kuo, L. Jing, S.-L. Chen, and C.-C. Tu,
“Biodegradable ICG-conjugated germanium nanoparticles for in
vivo near-infrared dual-modality imaging and photothermal
therapy,” ACS Appl. Mater. Interfaces 16, 59752-59764 (2024) [pdf] [link] |
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| 2. |
X. Tang, J. Zhou, S.
Liang, J. Zhang, J. Xiong, L. Ma, and S.-L. Chen, “All-fiber
miniature non-contact photoacoustic probe based on photoacoustic remote
sensing microscopy for vascular imaging in vivo,” Opt. Lett.
49, 5531-5534 (2024) [pdf]
[link] |
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| 3. |
Y. Liu, J. Zhou, Y.
Luo, J. Li, S.-L. Chen, Y. Guo, G.-Z. Yang, “UPAMNet: A
unified network with deep knowledge priors for photoacoustic
microscopy,” Photoacoustics 38, 100608 (2024) [pdf]
[link] |
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| 2023 |
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| 1. |
[G. Chen, L. Wang], P.
He, T. Su, Q. Lai, H.-C. Kuo, W. Wu, S.-L. Chen, and C.-C. Tu,
“Biodistributions and imaging of poly(Ethylene
glycol)-conjugated silicon quantum dot nanoparticles in osteosarcoma
models via intravenous and intratumoral injections,” ACS
Appl. Bio. Mater. 6, 4856-4866 (2023) [pdf]
[link] |
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| 2. |
[P. He, G. Chen], M. Huang, L. Jing, W. Wu, H.-C. Kuo, C.-C. Tu, and
S.-L. Chen, "Biodegradable germanium nanoparticles as contrast agents
for near-infrared-II photoacoustic imaging," Nanoscale 15, 11544-11559
(2023) [pdf]
[link] |
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| 3. |
N. Wan, M. Seong, K. Zhang, W. Niu, R. Wu, and S.-L. Chen, "Sensing of
triglyceride concentration in blood solution using photoacoustic
microscopy," Opt. Lett. 48, 3769-3772 (2023) [pdf]
[link] |
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| 4. |
[N. Wan, P. Zhang], Z. Liu, Z. Li, W. Niu, X. Rui, S. Wang, M. Seong,
P. He, S. Liang, J. Zhou, R. Yang, and S.-L. Chen, "Implantable QR code
subcutaneous microchip using photoacoustic and ultrasound microscopy
for secure and convenient individual identification and
authentication," Photoacoustics 31, 100504 (2023) [pdf]
[link] |
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| 5. |
S. Liang, J. Zhou, Z. Guo, D. He, W. Yang, Z. Ye, W. Shao, L. Jing, and
S.-L. Chen, "Miniature probe for optomechanical focus-adjustable
optical-resolution photoacoustic endoscopy," IEEE Trans. Med. Imaging
42, 2400-2413 (2023) [pdf]
[link] |
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| 6. |
[D. He, J. Zhou], X. Shang, X. Tang, J. Luo, and S.-L. Chen,
"De-noising of photoacoustic microscopy images by attentive generative
adversarial network," IEEE Trans. Med. Imaging 42, 1349-1362 (2023) [pdf]
[link] |
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| 2022 |
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| 1. |
B. Qin, S.-L. Chen, P. Miao, and Z. Teng, "Editorial: Cerebral vessel
extraction-from image acquisition to machine learning," Front.
Neurosci. 16, 972389 (2022) [pdf]
[link]
(Editorial) |
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| 2. |
[Z. Li, P. He], Y. Xu, Y. Deng, Y. Gao, and S.-L. Chen, "In vivo
evaluation of a lipopolysaccharide-induced ear vascular leakage model
in mice using photoacoustic microscopy," Biomed. Opt. Express 13,
4802-4816 (2022) [pdf]
[link] |
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| 3. |
J. Zhou, Y. Zhao, H. Liu, X. Tang, S.-L. Chen, and S.-H. Bo, "Rapid 3D
nondestructive imaging technology for batteries: Photoacoustic
microscopy," J. Mater. Res. 37, 3283-3296 (2022) [pdf]
[link] |
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| 4. |
[F. Feng, S. Liang], J. Luo, and S.-L. Chen, "High-fidelity
deconvolution for acoustic-resolution photoacoustic microscopy enabled
by convolutional neural networks," Photoacoustics 26, 100360 (2022) [pdf]
[link] |
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| 5. |
[F. Feng, S. Liang], and S.-L. Chen, "Image enhancement in
acoustic-resolution photoacoustic microscopy enabled by a novel
directional algorithm," Biomed. Opt. Express 13, 1026-1044 (2022) [pdf]
[link] |
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| 6. |
M. Seong, W. Yang, Y. Han, J. Zhou, L. Jing, and S.-L. Chen,
"Investigation of nonlinear photoacoustic microscopy using a low-cost
infrared lamp," J. Biophotonics 15, e202100301 (2022) [pdf]
[link] |
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| 7. |
S. Liang, J. Zhou, W. Yang, and S.-L. Chen, "Cerebrovascular imaging in
vivo by non-contact photoacoustic microscopy based on photoacoustic
remote sensing with a laser diode for interrogation," Opt. Lett. 47,
18-21 (2022) [pdf]
[link] |
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| 2021 |
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| 1. |
J. Zhou, J. Zhou, W. Wang, S. Liang, L. Jing, S.-H. Bo, and S.-L. Chen,
"Miniature non-contact photoacoustic probe based on fiber-optic
photoacoustic remote sensing microscopy," Opt. Lett. 46, 5767-5770
(2021) [pdf] |
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| 2. |
Y. Zhao, Y. Wu, H. Liu, S.-L. Chen, and S.-H. Bo, "Accelerated growth
of electrically isolated lithium metal during battery cycling," ACS
Appl. Mater. Interfaces 13, 35750-35758 (2021) [pdf] |
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| 3. |
[W. Yang, W. Wang], L. Jing, and S.-L. Chen, "Label-free photoacoustic
microscopy: A potential tool for the live imaging of blood disorders in
zebrafish," Biomed. Opt. Express 12, 3643-3657 (2021) [pdf] |
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| 4. |
W. Yang, J. Zhou, W. Shao, M. Seong, P. He, Z. Ye, Z. Guo, L. Jing, and
S.-L. Chen, "Photoacoustic-fluorescence microendoscopy in vivo," Opt.
Lett. 46, 2340-2343 (2021) [pdf] |
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| 5. |
N. Wan, M. Seong, and S.-L. Chen, "Theoretical investigation of
photoacoustics from cancer cells: modified models," IEEE J. Sel. Top.
Quantum Electron. 27, 7300410 (2021) [pdf] |
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| 6. |
S.-L. Chen and C. Tian, "Recent developments in photoacoustic imaging
and sensing for nondestructive testing and evaluation," Vis. Comput.
Ind. Biomed. Art 4, 6 (2021) [pdf] |
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| 7. |
J. Zhou, W. Wang, L. Jing, and S.-L. Chen, "Dual-modal imaging with
non-contact photoacoustic microscopy and fluorescence microscopy," Opt.
Lett. 46, 997-1000 (2021) [pdf] |
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| 8. |
[J. Zhou, D. He], X. Shang, Z. Guo, S.-L. Chen, and J. Luo,
"Photoacoustic microscopy with sparse data enabled by convolutional
neural networks," Photoacoustics 22, 100242 (2021) [pdf] |
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| 2020 |
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| 1. |
[D. He, D. Cai], J. Zhou, J. Luo, and S.-L. Chen, "Restoration of
out-of-focus fluorescence microscopy images using learning-based
depth-variant deconvolution," IEEE Photonics J. 12, 3900113 (2020) [pdf] |
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| 2. |
W. Yang and S.-L. Chen, "Time-gated fluorescence imaging: advances in
technology and biological applications," J. Innov. Opt. Heal. Sci.,
2030006 (2020) [pdf] |
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| 3. |
M. Seong and S.-L. Chen, "Recent advances toward clinical applications
of photoacoustic microscopy: a review," Sci. China Life Sci. 63,
1798-1812 (2020) [pdf] |
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| 4. |
G. Li, Z. Ye, S. Liang, and S.-L. Chen, "Miniature probe for
dual-modality photoacoustic microscopy and white-light microscopy for
image guidance: a prototype toward an endoscope," J. Biophotonics 13,
e201960200 (2020) [pdf] |
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| 5. |
[H. Liu, Y. Zhao], J. Zhou, P. Li, S.-H. Bo, and S.-L. Chen,
"Photoacoustic imaging of lithium metal batteries," ACS Appl. Energy
Mater. 3, 1260-1264 (2020) [pdf] |
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| 2019 |
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| 1. |
Z. Ye, P. K. Srivastava, Y. Xu, W. Wang, L. Jing, S.-L. Chen, and C.-C.
Tu, "Surface-functionalized silicon nanoparticles as contrast agents
for photoacoustic microscopy imaging," ACS Appl. Nano Mater. 2,
7577-7584 (2019) [pdf] |
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| 2. |
W. Yang, P. K. Srivastava, S. Han, L. Jing, C.-C. Tu, and S.-L. Chen,
"Optomechanical time-gated fluorescence imaging using long-lived
silicon quantum dot nanoparticles," Anal. Chem. 91, 5499-5503 (2019) [pdf] |
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| 3. |
X. Tu, S.-L. Chen, C. Song, T. Huang, and L. J. Guo, "Ultrahigh Q
polymer microring resonators for biosensing applications," IEEE
Photonics J. 11, 4200110 (2019) [pdf] |
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| 4. |
G. Li, Z. Guo, and S.-L. Chen, "Miniature probe for forward-view
wide-field optical-resolution photoacoustic endoscopy," IEEE Sens. J.
19, 909-916 (2019) [pdf]
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| 5. |
[Z. Guo, Z. Li], Y. Deng, and S.-L. Chen, "Photoacoustic microscopy for
evaluating a lipopolysaccharide-induced inflammation model in mice," J.
Biophotonics 12, e201800251 (2019) [pdf] |
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| 2018 |
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| 1. |
[D. Cai, T. T. W. Wong], L. Zhu, J. Shi, S.-L. Chen, and L. V. Wang,
"Dual-view photoacoustic microscopy for quantitative cell nuclear
imaging," Opt. Lett. 43, 4875-4878 (2018) [pdf] |
|
| 2. |
Y. Li, Z. Guo, G. Li, and S.-L. Chen, "Miniature fiber-optic
high-intensity focused ultrasound device using a candle soot
nanoparticles-polydimethylsiloxane composites-coated photoacoustic
lens," Opt. Express 26, 21700-21711 (2018) [pdf] |
|
| 3. |
Z. Guo, G. Li, and S.-L. Chen, "Miniature probe for all-optical double
gradient-index lenses photoacoustic microscopy," J. Biophotonics 11,
e201800147 (2018) [pdf] |
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| 4. |
Z. Guo, Y. Li, and S.-L. Chen, "Miniature probe for in vivo
optical- and acoustic-resolution photoacoustic microscopy," Opt. Lett.
43, 1119-1122 (2018) [pdf] |
|
| 5. |
X. Zhou, D. Cai, X. He, S.-L. Chen, X. Wang, and T. Yang, "Ultrasound
detection at fiber end-facets with surface plasmon resonance cavities,"
Opt. Lett. 43, 775-778 (2018) [pdf] |
|
| 6. |
S.-L. Chen, "Photoacoustic imaging by use of micro-electro-mechanical
system scanner," J. Shanghai Jiao Tong Univ. (Sci.) 23, 1-10 (2018) [pdf] |
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7. |
T. Yang, X. He, X. Zhou, Z. Lei, Y. Wang, J. Yang, D. Cai, S.-L. Chen,
and X. Wang, "Surface plasmon cavities on optical fiber end-facets for
biomolecule and ultrasound detection," Opt. Laser Technol. 101, 468-478
(2018) [pdf] |
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| 2017 |
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| 1. |
G. Li, Z. Guo, and S.-L. Chen, "Miniature all-optical probe for large
synthetic aperture photoacoustic-ultrasound imaging," Opt. Express 25,
25023-25035 (2017) [pdf] |
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| 2. |
D. Cai, G. Li, D. Xia, Z. Li, Z. Guo, and S.-L. Chen, "Synthetic
aperture focusing technique for photoacoustic endoscopy," Opt. Express
25, 20162-20171 (2017) [pdf] |
|
| 3. |
D. Cai, Z. Li, Y. Li, Z. Guo, and S.-L. Chen, "Photoacoustic
microscopy in vivo using synthetic-aperture
focusing technique combined with three-dimensional deconvolution," Opt. Express 25, 1421-1434
(2017) [pdf] |
|
| 4. |
S.-L.
Chen, "Review of laser-generated ultrasound transmitters and their
applications to all-optical ultrasound transducers and imaging,"
Appl.
Sci. 7, 25 (2017) [pdf] |
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| 2016 |
|
| 1. |
A. Rahimzadeh and S.-L. Chen, "Finite-difference
time-domain solution of second-order photoacoustic wave equation," Optica Applicata 46, 435-446
(2016) [pdf] |
|
| 2. |
D.
Cai, Z. Li, and S.-L. Chen, "In vivo deconvolution
acoustic-resolution photoacoustic microscopy in three dimensions,"
Biomed.
Opt. Express 7, 369-380 (2016) [pdf] |
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| 2015 |
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| 1. |
S.-L.
Chen, L. J. Guo, and X. Wang, "All-optical photoacoustic microscopy,"
Photoacoustics
3, 143-150
(2015) [pdf]
(Invited Paper) |
|
| 2. |
C.
Zhang, S.-L. Chen, T. Ling, and L. J. Guo, "Imprinted polymer
microrings as high-performance ultrasound detectors in photoacoustic
imaging," J. Lightwave Technol. 33, 4318-4328 (2015) [pdf]
(Invited Paper) |
|
| 3. |
D.
Cai, Z. Li, and S.-L. Chen, "Photoacoustic microscopy by scanning
mirror-based synthetic aperture focusing technique," Chin. Opt. Lett.
13, 101101 (2015) [pdf] |
|
| 4. |
C.
Zhang, S.-L. Chen, T. Ling, and L. J. Guo, "Review of imprinted polymer
microring as ultrasound detector: design, fabrication, and
characterization," IEEE Sensors J. 15, 3241-3248 (2015) [pdf]
(Invited Paper) |
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| 2014 |
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| 1. |
C. Zhang, T.
Ling, S.-L. Chen, and L. J. Guo, "Ultrabroad bandwidth and highly
sensitive optical ultrasonic detector for photoacoustic imaging," ACS
Photonics 1, 1093-1098 (2014) [pdf] |
|
| 2. |
S.-L. Chen,
Y.-C. Chang, C.
Zhang, J. G. Ok, T. Ling, M.
T. Mihnev, T. B. Norris, and L. J. Guo, "Efficient real-time detection
of terahertz pulse radiation based on photoacoustic conversion by
carbon nanotube nanocomposite," Nat. Photonics 8, 537-542 (2014) [link]
(reported by
Gizmag Emerging Technology Magazine,
Michigan News, R&D Magazine,
Radiology Daily,
Science Daily) |
|
| 3. |
B.-Y. Hsieh,
S.-L. Chen, T. Ling, L. J. Guo, and P.-C. Li, "All-optical scanhead for
ultrasound and photoacoustic imaging-Imaging mode switching by dichroic
filtering," Photoacoustics 2, 39-46 (2014) [pdf]
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| Before 2013 |
|
| 1.
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S.-L.
Chen, J. Burnett, D. Sun, X. Wei, Z. Xie, and X. Wang,
"Photoacoustic microscopy: a potential new tool for evaluation of
angiogenesis inhibitor," Biomed. Opt. Express 4, 2657-2666 (2013) [pdf]
|
|
| 2. |
Z.
Xie, S.-L. Chen, M. L. Fabiilli, J. B. Fowlkes, K. K. Shung, Q. Zhou,
P. L. Carson, and X. Wang, "Simultaneous viewing
of individual cells and ambient microvasculature using optical
absorption and fluorescence contrasts," Mol. Imaging 12, 491-496 (2013)
[pdf]
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| 3.
|
S.-L.
Chen, Z. Xie, L. J. Guo, and X. Wang, "A fiber-optic system
for dual-modality photoacoustic microscopy and confocal fluorescence
microscopy using miniature components," Photoacoustics 1, 30-35 (2013) [pdf]
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| 4.
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S.-L.
Chen, Z. Xie, T. Ling, L. J. Guo, X. Wei, and X. Wang,
"Miniaturized all-optical photoacoustic microscopy based on
microelectromechanical systems mirror scanning," Opt. Lett. 37,
4263-4265 (2012) [pdf]
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|
| 5.
|
B.-Y.
Hsieh, S.-L. Chen, T. Ling, L. J. Guo, and P.-C. Li,
"All-optical scanhead for ultrasound and photoacoustic dual-modality
imaging," Opt. Express 20, 1588-1596 (2012) [pdf]
|
|
| 6. |
S.-L.
Chen, Z. Xie, P. L. Carson, X. Wang, and L. J. Guo, "In
vivo flow speed measurement of capillaries by photoacoustic
correlation spectroscopy," Opt. Lett. 36, 4017-4019 (2011) [pdf]
|
|
| 7. |
T.
Ling, S.-L. Chen, and L. J. Guo, "High-sensitivity and wide-directivity
ultrasound detection using high Q polymer micro-ring resonators," Appl.
Phys. Lett. 98, 204103 (2011) [pdf]
|
|
| 8. |
S.-L.
Chen, T. Ling, and L. J. Guo, "Low-noise small size microring
ultrasonic detectors for high resolution photoacoustic imaging," J.
Biomed. Opt. 16, 056001 (2011) [pdf]
|
|
| 9. |
Z.
Xie, S.-L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, "Pure
optical photoacoustic microscopy," Opt. Express 19, 9027-9034 (2011)
[pdf]
|
|
| 10. |
T.
Ling, S.-L. Chen, and L. J. Guo, "Fabrication and characterization of high Q
polymer micro-ring resonator and its application as a sensitive
ultrasonic detector," Opt. Express 19, 861-869 (2011)
[pdf]
|
|
| 11. |
H.
W. Baac, J. G. Ok, H. J. Park, T. Ling, S.-L. Chen, A. J. Hart, and L.
J. Guo, "Carbon nanotube composite optoacoustic transmitters for strong
and high frequency ultrasound generation," Appl. Phys. Lett. 97, 234104
(2010) [pdf]
|
|
| 12. |
B.-Y.
Hsieh, S.-L. Chen, T. Ling, L. J. Guo, and P.-C. Li, "Integrated
intravascular ultrasound and photoacoustic imaging scan head," Opt.
Lett. 35, 2892-2894 (2010) [pdf]
|
|
| 13. |
S.-L.
Chen, T. Ling, S.-W. Huang, H. W. Baac, and L. J. Guo, "Photoacoustic
correlation spectroscopy and its applications to low speed flow
measurement," Opt. Lett. 35, 1200-1202 (2010) [pdf]
|
|
| 14. |
S.-L.
Chen, S.-W. Huang, T. Ling, S. Ashkenazi, and L. J. Guo, "Polymer
microring resonators for high-sensitivity and wideband photoacoustic
imaging," IEEE Trans. Ultrason., Ferroelectr., Freq. Control. 56,
2482-2491 (2009) [pdf]
|
|
| 15.
|
S.-W.
Huang, S.-L. Chen, T. Ling, A. Maxwell, M. O'Donnell, L. J. Guo, and S.
Ashkenazi, "Low-noise wideband ultrasound detection using polymer
microring resonators," Appl. Phys. Lett. 92, 193509 (2008) [pdf]
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| Book Chapters |
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| 1.
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S.-L. Chen and L. J. Guo, "Terahertz Pulse Detection
Techniques and Imaging Applications,"
Chapter 11 of the book - Terahertz Spectroscopy - Cutting Edge
Technology (2017) [pdf]
[link]
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Copyright (C) 2026 Global College
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